Gustavo Moraga Cid

Profesor asociado
Doctor en Ciencias Biológicas, Área biología celular y molecular, Universidad de Concepción

Edificio del Arco, 3er piso. Departamento de Fisiología
(+56-41)220 – 1713
gumoraga@udec.cl
Laboratorio de Neurofarmacología Estructural

Miembro de la Sociedad de Biología Celular y de la Sociedad de Farmacología de Chile.
Miembro de la Society for Neuroscience.

Pregrado

  • Pedagogía en Cs. Naturales y Biología
  • Nutrición
  • Bioingeniería
  • Enfermería
  • Tecnología Médica
  • Medicina 

Postgrado

  • Doctorado en Ciencias Biológicas área Biología Celular y Molecular
  • Magíster en Neurobiología

 

 

  • Organización de actividades en torno al Brain Awareness Week 2017
  • Participación en iniciativa 1000 cientificos 1000 aulas
  • Charlas en colegios de la ciudad

Líneas de Investigación

Durante su doctorado se centró en la modulación de canales iónicos por etanol y anestésicos generales, para luego dedicarse a la estructura de proteínas de membrana y canales iónicos. Actualmente se dedica a estudiar la farmacología estructural de canales iónicos en búsqueda y diseño racional de moduladores alostéricos de canales iónicos activados por ligando.

Proyectos

    • PI: Fondecyt Regular 1160851 (2016) Deciphering The Functional And Structural Properties Of The Large Intracellular Domain Of The Pentameric Ligand Gated Receptors. Investigador Alterno ECOS CONICYT C16S01 “Abeta assemblies propagation and cell damage in Alzheimer’s Disease”

Publicaciones

1. Moraga-Cid G, et al. Structural basis for hyperekplexia allosteric mutant phenotypes in the

human α1 glycine receptor. 2014. PNAS 2015. 112(9):2865-70

2. Sánchez A, Yévenes GE, San Martin L, Burgos CF, Moraga-Cid G, et al. Control of ethanol

sensitivity of the glycine receptor α3 subunit by the intracellular spliced cassette and C-
terminus domain. 2014. J Pharmacol Exp Ther. 2015. 353(1):80-90..

3. Prevost MS, Moraga-Cid G, et al. Intermediate closed state for glycine receptor function

revealed by cysteine cross-linking. 2013. PNAS 110:17113-8.

4. Sauguet L, Poitevin F, Murail S, Van Renterghem C, Moraga-Cid G, et al. Structural basis for

ion permeation mechanism in pentameric ligand-gated ion channels. 2013. EMBO J. 32:728-

41

5. Moraga-Cid, G, et al. A Single Phenylalanine Residue in the M3-M4 Loop of the α1 Subunits

on GABAA and Glycine Receptors Is Determinant for Propofol Sensitivity. 2011.

Anesthesiology. 115:464-73.

6. Duret G, Van Renterghem C, Weng Y, Prevost M, Moraga-Cid G, et al. Functional

prokaryotic-eukaryotic chimera from the pentameric ligand-gated ion channel family. 2011.

PNAS. 128:12143-48

7. Calero CI, Vickers E, Moraga-Cid G, et al. Allosteric Modulation of Retinal GABA Receptors

by Ascorbic Acid. J Neurosci. 2011. 31:9672-82.

8. Yevenes GE, Moraga-Cid G, et al. Activated G protein {alpha}s subunits increase the ethanol

sensitivity of human glycine receptors. J Pharmacol Exp Ther. 2011. 339:386-93

9. Fuentealba J, Muñoz B, Yévenes G, Moraga-Cid G, et al. Potentiation and inhibition of

glycine receptors by tutin. Neuropharmacology. 2010. 60:453-459.

10. Yevenes GE*, Moraga-Cid G*, et al. Molecular requirements for ethanol differential allosteric

modulation of glycine receptors based on selective Gbetagamma modulation. J Biol Chem.

2010 285:30203-13. * Equal contribution.

11. Avila ME, Sepúlveda FJ, Burgos CF, Moraga-Cid G, et al. Canonical Wnt3a modulates

intracellular calcium and enhances excitatory neurotransmission in hippocampal neurons. J

Biol Chem. 2010 285:18939-47.

12. Guzman L, Moraga-Cid G, et al. Blockade of ethanol-induced potentiation of glycine receptors

by a peptide that interferes with Gbetagamma binding. J Pharmacol Exp Ther. 2009.331:933-

9.

13. Yevenes GE, Moraga-Cid G, et al. A selective G betagamma-linked intracellularmechanism

for modulation of a ligand-gated ion channel by ethanol. PNAS. 2008. ;105:20523-8.

14. Yevenes GE, Moraga-Cid G, et al. Molecular determinants for G protein betagamma

modulation of ionotropic glycine receptors. J Biol Chem. 2006. 281:39300-7.

15. Godoy A, Ormazabal V, Moraga-Cid G, et al. Mechanistic insights and functional

determinants of the transport cycle of the ascorbic acid transporter SVCT2. Activation by

sodium and absolute dependence on bivalent cations. J Biol Chem. 2007. 282:615-24.

16. Orrego R, Burgos A, Moraga-Cid G, Inzunza B, Gonzalez M, Valenzuela A, Barra R, Gavilán

JF. Effects of pulp and paper mill discharges on caged rainbow trout (Oncorhynchus mykiss):

biomarker responses along a pollution gradient in the Biobio River, Chile. ETC. 2006.

25:2280-7.

17. Oñate AA, Donoso G, Moraga-Cid G, Folch H, Céspedes S, Andrews E. An RNA vaccine

based on recombinant Semliki Forest virus particles expressing the Cu,Zn superoxide

dismutase protein of Brucella abortus induces protective immunity in BALB/c mice. Infect

Immun. 2005. 73(6):3294-300.

18. Orrego R, Moraga-Cid G, González M, Barra R, Valenzuela A, Burgos A, Gavilán JF.

Reproductive, physiological, and biochemical responses in juvenile female rainbow trout

(Oncorhynchus mykiss) exposed to sediment from pulp and paper mill industrial discharge

areas. ETC. 2005 24:1935-43.

19. Muñoz-Montesino C, Andrews E, Rivers R, González-Smith A, Moraga-Cid G, Folch H,

Céspedes S, Oñate AA. Intraspleen delivery of a DNA vaccine coding for superoxide

dismutase (SOD) of Brucella abortus induces SOD-specific CD4+ and CD8+ T cells. Infect

Immun. 2004. 72:2081-7.

Laboratorio

Laboratorio de Neurofarmacología Estructural

• Equipo de trabajo:
o David Flaig (Técnico de Laboratorio)
o Marcelo Cáceres (Tesista Bioingeniería)